兒童急性淋巴細胞白血病血小板參數(shù)及血小板膜糖蛋白臨床意義研究
[Abstract]:Objective to investigate the changes of platelet activation and function in children with acute lymphocytic leukemia (ALL). Methods the children with ALL were detected by automatic blood cell analyzer and flow cytometry (FCM) microblood method from June 2012 to November 2013 in the affiliated Hospital of Southwest Medical University (ALL group). Platelet parameters, percentage of reticulated platelets (IPF%) and absolute value of reticular platelet membrane glycoprotein (CD62p) in children with complete remission by ALL induced remission (ALL-CR1 group) and surgical elective surgery (normal group). PAC-1. Results before adenosine diphosphate (ADP) activation, the expression of CD62p,PAC-1 in ALL group was higher than that in normal group (P 0.05), and the expression of PAC-1 in ALL-CR1 group was higher than that in normal group (P 0.05), which was lower than that in ALL group (P 0.05). After ADP activation, the expression of CD62p,PAC-1 in ALL group was lower than that in normal group (P 0.05), and the expression of PAC-1 in ALL-CR1 group was lower than that in normal group (P 0.05), which was higher than that in ALL group (P 0.05). The mean platelet volume of (PLT), platelet volume (PCT), in ALL group was lower than that in normal group and ALL-CR1 group (P 0.05). IPF% in ALL group was higher than that in normal group and ALL-CR1 group (P 0.05), IPC was lower than that in normal group and ALL-CR1 group (P 0.05). Conclusion Platelet activation and abnormal platelet function are found in the newly diagnosed children with ALL. Platelet parameters and platelet membrane glycoprotein can be used as effective indexes to judge the curative effect of ALL.
【作者單位】: 西南醫(yī)科大學(xué)附屬醫(yī)院兒一科;西南醫(yī)科大學(xué)附屬醫(yī)院感染呼吸科;四川省資陽市中心血站;四川省綿陽市中心醫(yī)院;
【基金】:四川省衛(wèi)生廳科研基金資助(20110004)
【分類號】:R733.71
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