重癥急性胰腺炎SIRS大鼠中性粒細(xì)胞的鈣穩(wěn)態(tài)變化及大黃素的調(diào)節(jié)作用
發(fā)布時(shí)間:2020-12-01 17:04
背景和目的:重癥急性胰腺炎(severe acute pancreatitis, SAP)是一種發(fā)病急、進(jìn)展快、并發(fā)癥多、病死率高的臨床嚴(yán)重疾病。全身炎性反應(yīng)綜合征(systemicinflammatory response syndrome, SIRS)是SAP發(fā)展至多器官功能障礙綜合征(multiple organs dysfunction syndrome, MODS)的前期表現(xiàn),是其高病死率的主要原因。過(guò)度的炎性反應(yīng)可導(dǎo)致機(jī)體免疫功能下降,器官感染、功能受損等,進(jìn)而導(dǎo)致并發(fā)癥發(fā)生率明顯升高[1,2],進(jìn)一步加重SAP病情的發(fā)展,形成惡性循環(huán)。因此,阻斷SIRS向MODS的進(jìn)展是降低SAP高病死率的關(guān)鍵。多形核中性粒細(xì)胞(polymorphonuclear neutrophils, PMN),是炎癥反應(yīng)的重要效應(yīng)細(xì)胞,在炎癥的發(fā)生、發(fā)展和轉(zhuǎn)歸中起著關(guān)鍵的作用[3]。PMN凋亡障礙或延遲是SIRS的主要病理生理過(guò)程。鈣離子作為人體內(nèi)最普遍的信號(hào)轉(zhuǎn)導(dǎo)因子之一,調(diào)節(jié)著許多細(xì)胞和組織的生理活動(dòng),其穩(wěn)態(tài)失衡是細(xì)胞凋亡的關(guān)鍵環(huán)節(jié)之一。本實(shí)驗(yàn)旨在SAP所致的SIRS大鼠模型中,研究PMN細(xì)胞內(nèi)...
【文章來(lái)源】:大連醫(yī)科大學(xué)遼寧省
【文章頁(yè)數(shù)】:54 頁(yè)
【學(xué)位級(jí)別】:碩士
【部分圖文】:
正常大鼠與模型大鼠的大體解剖觀察
光鏡下胰腺組織病理學(xué)改變(HE染色20倍)
假手術(shù)組大鼠 SAP.SIRS 模型大鼠圖 1 正常大鼠與模型大鼠的大體解剖觀察假手術(shù)組 SAP.SIRS 模型組圖 2 光鏡下胰腺組織病理學(xué)改變(HE 染色 20 倍)
【參考文獻(xiàn)】:
期刊論文
[1]Influence of dexamethasone on mesenteric lymph node of rats with severe acute pancreatitis[J]. Xi-Ping Zhang, Yang Cai, Bei Lu, Qi Xie, Tong-Fa Ju, Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou 310006, Zhejiang Province, China Hong-Miao Xu, Graduate at Department of Stomotology, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China Yi-Yu Jiang, Zhejiang Traditional Chinese Medicine University, Hangzhou 310053, Zhejiang Province, China Shuo Yu, Class 01 of Clinical Medicine Department, Zhejiang University, Hangzhou 310029, Zhejiang Province, China. World Journal of Gastroenterology. 2008(22)
[2]地塞米松對(duì)大鼠急性肺損傷中性粒細(xì)胞凋亡的影響[J]. 葉正龍,徐巧蓮,邱海波,李士榮,陳留信. 江蘇醫(yī)藥. 2007(02)
[3]大黃素對(duì)急性壞死性胰腺炎大鼠肺炎性細(xì)胞因子的作用(英文)[J]. 周黎明,察雪湘,萬(wàn)莉紅,朱玲,匡湘紅,周雪平,蔣俊明,王正榮. 航天醫(yī)學(xué)與醫(yī)學(xué)工程. 2006(04)
[4]大黃素對(duì)全身炎性反應(yīng)綜合征時(shí)中性粒細(xì)胞凋亡異常治療的研究[J]. 尚東,王寶枝,畢偉,陳海龍,齊清會(huì),關(guān)鳳林. 中國(guó)急救醫(yī)學(xué). 2006(08)
[5]全身炎性反應(yīng)綜合征時(shí)中性粒細(xì)胞凋亡的異常[J]. 尚東,王寶枝,畢偉,陳海龍,齊清會(huì),關(guān)鳳林. 大連醫(yī)科大學(xué)學(xué)報(bào). 2006(03)
[6]提高對(duì)重癥急性胰腺炎多臟器功能障礙的認(rèn)識(shí)及防治水平[J]. 王春友. 中國(guó)實(shí)用外科雜志. 2006(05)
[7]大黃素對(duì)大鼠急性壞死型胰腺炎的干預(yù)作用[J]. 周黎明,萬(wàn)莉紅,李貴星,王正榮. 中藥藥理與臨床. 2006(02)
[8]大黃素對(duì)急性胰腺炎大鼠胰腺核因子-kB活化的影響[J]. 滿曉華,李兆申,屠振興,賈一韜,龔燕芳. 中華消化雜志. 2005(10)
[9]Effects of emodin and baicalein on rats with severe acute pancreatitis[J]. Xi-Ping Zhang, Department of General Surgery,First People’s Hospital of Hangzhou, Hangzhou 310006, Zhejiang Province, China Zhong-Fang Li, Xiao-Gong Liu, Yong-Tao Wu, Department of General Surgery, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China Jun-Xian Wang, Pharmaceutical College of Xi’an Jiaotong University, Xi’an 710016, Shaanxi Province, China Kang-Min Wang, Department of Pathology, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China Yi-Feng Zhou, Department of Digestion, First People’s Hospital of Hangzhou, Hangzhou 310006, Zhejiang Province, China. World Journal of Gastroenterology. 2005(14)
[10]鈣離子信號(hào)與細(xì)胞凋亡[J]. 郭靜,蒲詠梅,張東才. 生物物理學(xué)報(bào). 2005(01)
[1]黃家駟外科學(xué)[M]. 人民衛(wèi)生出版社 , 吳孟超, 2008
本文編號(hào):2894950
【文章來(lái)源】:大連醫(yī)科大學(xué)遼寧省
【文章頁(yè)數(shù)】:54 頁(yè)
【學(xué)位級(jí)別】:碩士
【部分圖文】:
正常大鼠與模型大鼠的大體解剖觀察
光鏡下胰腺組織病理學(xué)改變(HE染色20倍)
假手術(shù)組大鼠 SAP.SIRS 模型大鼠圖 1 正常大鼠與模型大鼠的大體解剖觀察假手術(shù)組 SAP.SIRS 模型組圖 2 光鏡下胰腺組織病理學(xué)改變(HE 染色 20 倍)
【參考文獻(xiàn)】:
期刊論文
[1]Influence of dexamethasone on mesenteric lymph node of rats with severe acute pancreatitis[J]. Xi-Ping Zhang, Yang Cai, Bei Lu, Qi Xie, Tong-Fa Ju, Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou 310006, Zhejiang Province, China Hong-Miao Xu, Graduate at Department of Stomotology, The First Affiliated Hospital of College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China Yi-Yu Jiang, Zhejiang Traditional Chinese Medicine University, Hangzhou 310053, Zhejiang Province, China Shuo Yu, Class 01 of Clinical Medicine Department, Zhejiang University, Hangzhou 310029, Zhejiang Province, China. World Journal of Gastroenterology. 2008(22)
[2]地塞米松對(duì)大鼠急性肺損傷中性粒細(xì)胞凋亡的影響[J]. 葉正龍,徐巧蓮,邱海波,李士榮,陳留信. 江蘇醫(yī)藥. 2007(02)
[3]大黃素對(duì)急性壞死性胰腺炎大鼠肺炎性細(xì)胞因子的作用(英文)[J]. 周黎明,察雪湘,萬(wàn)莉紅,朱玲,匡湘紅,周雪平,蔣俊明,王正榮. 航天醫(yī)學(xué)與醫(yī)學(xué)工程. 2006(04)
[4]大黃素對(duì)全身炎性反應(yīng)綜合征時(shí)中性粒細(xì)胞凋亡異常治療的研究[J]. 尚東,王寶枝,畢偉,陳海龍,齊清會(huì),關(guān)鳳林. 中國(guó)急救醫(yī)學(xué). 2006(08)
[5]全身炎性反應(yīng)綜合征時(shí)中性粒細(xì)胞凋亡的異常[J]. 尚東,王寶枝,畢偉,陳海龍,齊清會(huì),關(guān)鳳林. 大連醫(yī)科大學(xué)學(xué)報(bào). 2006(03)
[6]提高對(duì)重癥急性胰腺炎多臟器功能障礙的認(rèn)識(shí)及防治水平[J]. 王春友. 中國(guó)實(shí)用外科雜志. 2006(05)
[7]大黃素對(duì)大鼠急性壞死型胰腺炎的干預(yù)作用[J]. 周黎明,萬(wàn)莉紅,李貴星,王正榮. 中藥藥理與臨床. 2006(02)
[8]大黃素對(duì)急性胰腺炎大鼠胰腺核因子-kB活化的影響[J]. 滿曉華,李兆申,屠振興,賈一韜,龔燕芳. 中華消化雜志. 2005(10)
[9]Effects of emodin and baicalein on rats with severe acute pancreatitis[J]. Xi-Ping Zhang, Department of General Surgery,First People’s Hospital of Hangzhou, Hangzhou 310006, Zhejiang Province, China Zhong-Fang Li, Xiao-Gong Liu, Yong-Tao Wu, Department of General Surgery, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China Jun-Xian Wang, Pharmaceutical College of Xi’an Jiaotong University, Xi’an 710016, Shaanxi Province, China Kang-Min Wang, Department of Pathology, Second Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China Yi-Feng Zhou, Department of Digestion, First People’s Hospital of Hangzhou, Hangzhou 310006, Zhejiang Province, China. World Journal of Gastroenterology. 2005(14)
[10]鈣離子信號(hào)與細(xì)胞凋亡[J]. 郭靜,蒲詠梅,張東才. 生物物理學(xué)報(bào). 2005(01)
[1]黃家駟外科學(xué)[M]. 人民衛(wèi)生出版社 , 吳孟超, 2008
本文編號(hào):2894950
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