天然小分子化合物調(diào)節(jié)小膠質(zhì)細胞預(yù)防阿爾茨海默病免疫失衡（英文）
發(fā)布時間：2020-12-04 13:31
阿爾茨海默病(Alzheimer’s disease,AD)是最常見的中樞神經(jīng)系統(tǒng)退行性疾病,其發(fā)病機制復(fù)雜,至今仍未完全闡明.最近的研究表明,小膠質(zhì)細胞過度激活、炎癥因子的過度產(chǎn)生與AD的發(fā)病密切相關(guān).小膠質(zhì)細胞受體及下游通路的異常調(diào)節(jié)可導(dǎo)致AD患者及AD實驗動物的免疫失衡.天然小分子化合物通過激活小膠質(zhì)細胞的抑炎受體,抑制促炎受體或調(diào)節(jié)Aβ清除受體,可逆轉(zhuǎn)免疫失衡.本文綜述了小膠質(zhì)細胞在AD慢性炎癥中的作用機制,并總結(jié)天然小分子化合物通過調(diào)節(jié)小膠質(zhì)細胞受體及其下游通路在AD免疫穩(wěn)態(tài)中的有益作用.
【文章來源】：生物化學(xué)與生物物理進展. 2020年08期 第712-728頁 北大核心
【文章頁數(shù)】：17 頁
【文章目錄】：
1 The inflammatory response is a key factor in the pathogenesis of Alzheimer’s disease
2 Improper regulation of microglial receptors and their downstream pathways impair immune homeostasis in AD
2.1 Increase release of inflammatory cytokines via activation of microglial pro-inflammatory receptors and their downstream pathways in AD
2.2 Decrease expression of anti-inflammatory receptors in microglia aggravate the imbalance of inflammatory cytokines in AD
2.3 Improper regulation of the Aβclearance receptor in microglia promote the progress of AD
3 Natural small-molecule compounds regulate the pathological process of Alzheimer’s disease by maintaining immune homeostasis
3.1 Natural small-molecule compounds inhibit the activation of microglial pro-inflammatory receptors and their downstream pathways in AD
3.2 Natural small-molecule compounds activate microglial anti-inflammatory receptors and its downstream pathways in AD
3.3 Natural small-molecule compounds show its benefit effects through regulate the receptors involved in Aβclearance in AD
4 Summary and prospect
【參考文獻】：
期刊論文
[1]Nature brings new avenues to the therapy of central nervous system diseases——an overview of possible treatments derived from natural products[J]. Junchi Zhang,Yang He,Xiangrui Jiang,Hualiang Jiang,Jingshan Shen. Science China(Life Sciences). 2019(10)
[2]Herbal decoctosome is a novel form of medicine[J]. Xiaoyun Li,Zhu Liang,Jianchao Du,Zhiqing Wang,Song Mei,Zhiqing Li,Yan Zhao,DANDan Zhao,Yiming Ma,Jun Ye,Jiantao Xu,Yu Zhao,Jiahui Chang,Yuhao Qin,Lanlan Yu,Chenxuan Wang,Chengyu Jiang. Science China(Life Sciences). 2019(03)
[3]模式識別受體激活狀態(tài)對小膠質(zhì)細胞p38-MAPK磷酸化水平的影響[J]. 鄭翰軒,張郃. 生物技術(shù)進展. 2018(02)
[4]Celastrol specifically inhibits the activation of NLRP3 inflammasome[J]. Xuesong Sang,Yihui Chen,Wei Chen,Jing Xie,Guangxun Meng,Jin Zhong,Taisheng Li,Ailing Lu. Science China(Life Sciences). 2018(03)
[5]川芎嗪通過抑制RAGE-ERK1/2-p38-NFκB信號通路及活性氧生成改善阿爾茨海默病大鼠腦組織炎性[J]. 劉長安,朱潔,蔡標,黃金玲. 中國藥學(xué)雜志. 2014(13)
[6]遠志總皂苷對AD模型大鼠學(xué)習(xí)記憶及海馬nAChRα7亞基的影響[J]. 趙大鵬,李曉峰,陳樹沙,景瑋,邢婕,穆俊霞,李新毅. 中國神經(jīng)免疫學(xué)和神經(jīng)病學(xué)雜志. 2012(05)
[7]紅景天苷對Aβ1～40所致阿爾茨海默病模型大鼠認知功能改善作用及機制探討[J]. 張佳,宋立剛,孔衛(wèi)娜,邵鐵梅,溫昕,劉培,柴錫慶. 中國中藥雜志. 2012(14)
[8]大豆異黃酮對阿爾茨海默病大鼠海馬RAGE介導(dǎo)的信號轉(zhuǎn)導(dǎo)通路的影響[J]. 劉長安,汪遠金,那莎,朱潔,蔡標. 中國中西醫(yī)結(jié)合雜志. 2012(06)
[9]燈盞乙素對癡呆大鼠腦組織乙酰膽堿尼古丁受體蛋白及mRNA表達的作用[J]. 郭莉莉,王永林,黃勇,官志忠. 中國中西醫(yī)結(jié)合雜志. 2011(06)
碩士論文
[1]Trem2激活促進抗炎和自噬改善阿爾茨海默病行為學(xué)的研究[D]. 辜敏.重慶醫(yī)科大學(xué) 2016
[2]吳茱萸堿對阿爾茨海默病模型大鼠HMGB1/TLR4/NF-κB信號通路的研究[D]. 孫文蕾.河北醫(yī)科大學(xué) 2015
[3]蛇床子素對阿爾茨海默病模型大鼠認知障礙的神經(jīng)保護作用及其機制研究[D]. 鄭為娜.河北醫(yī)科大學(xué) 2015
本文編號：2897694
【文章來源】：生物化學(xué)與生物物理進展. 2020年08期 第712-728頁 北大核心
【文章頁數(shù)】：17 頁
【文章目錄】：
1 The inflammatory response is a key factor in the pathogenesis of Alzheimer’s disease
2 Improper regulation of microglial receptors and their downstream pathways impair immune homeostasis in AD
2.1 Increase release of inflammatory cytokines via activation of microglial pro-inflammatory receptors and their downstream pathways in AD
2.2 Decrease expression of anti-inflammatory receptors in microglia aggravate the imbalance of inflammatory cytokines in AD
2.3 Improper regulation of the Aβclearance receptor in microglia promote the progress of AD
3 Natural small-molecule compounds regulate the pathological process of Alzheimer’s disease by maintaining immune homeostasis
3.1 Natural small-molecule compounds inhibit the activation of microglial pro-inflammatory receptors and their downstream pathways in AD
3.2 Natural small-molecule compounds activate microglial anti-inflammatory receptors and its downstream pathways in AD
3.3 Natural small-molecule compounds show its benefit effects through regulate the receptors involved in Aβclearance in AD
4 Summary and prospect
【參考文獻】：
期刊論文
[1]Nature brings new avenues to the therapy of central nervous system diseases——an overview of possible treatments derived from natural products[J]. Junchi Zhang,Yang He,Xiangrui Jiang,Hualiang Jiang,Jingshan Shen. Science China(Life Sciences). 2019(10)
[2]Herbal decoctosome is a novel form of medicine[J]. Xiaoyun Li,Zhu Liang,Jianchao Du,Zhiqing Wang,Song Mei,Zhiqing Li,Yan Zhao,DANDan Zhao,Yiming Ma,Jun Ye,Jiantao Xu,Yu Zhao,Jiahui Chang,Yuhao Qin,Lanlan Yu,Chenxuan Wang,Chengyu Jiang. Science China(Life Sciences). 2019(03)
[3]模式識別受體激活狀態(tài)對小膠質(zhì)細胞p38-MAPK磷酸化水平的影響[J]. 鄭翰軒,張郃. 生物技術(shù)進展. 2018(02)
[4]Celastrol specifically inhibits the activation of NLRP3 inflammasome[J]. Xuesong Sang,Yihui Chen,Wei Chen,Jing Xie,Guangxun Meng,Jin Zhong,Taisheng Li,Ailing Lu. Science China(Life Sciences). 2018(03)
[5]川芎嗪通過抑制RAGE-ERK1/2-p38-NFκB信號通路及活性氧生成改善阿爾茨海默病大鼠腦組織炎性[J]. 劉長安,朱潔,蔡標,黃金玲. 中國藥學(xué)雜志. 2014(13)
[6]遠志總皂苷對AD模型大鼠學(xué)習(xí)記憶及海馬nAChRα7亞基的影響[J]. 趙大鵬,李曉峰,陳樹沙,景瑋,邢婕,穆俊霞,李新毅. 中國神經(jīng)免疫學(xué)和神經(jīng)病學(xué)雜志. 2012(05)
[7]紅景天苷對Aβ1～40所致阿爾茨海默病模型大鼠認知功能改善作用及機制探討[J]. 張佳,宋立剛,孔衛(wèi)娜,邵鐵梅,溫昕,劉培,柴錫慶. 中國中藥雜志. 2012(14)
[8]大豆異黃酮對阿爾茨海默病大鼠海馬RAGE介導(dǎo)的信號轉(zhuǎn)導(dǎo)通路的影響[J]. 劉長安,汪遠金,那莎,朱潔,蔡標. 中國中西醫(yī)結(jié)合雜志. 2012(06)
[9]燈盞乙素對癡呆大鼠腦組織乙酰膽堿尼古丁受體蛋白及mRNA表達的作用[J]. 郭莉莉,王永林,黃勇,官志忠. 中國中西醫(yī)結(jié)合雜志. 2011(06)
碩士論文
[1]Trem2激活促進抗炎和自噬改善阿爾茨海默病行為學(xué)的研究[D]. 辜敏.重慶醫(yī)科大學(xué) 2016
[2]吳茱萸堿對阿爾茨海默病模型大鼠HMGB1/TLR4/NF-κB信號通路的研究[D]. 孫文蕾.河北醫(yī)科大學(xué) 2015
[3]蛇床子素對阿爾茨海默病模型大鼠認知障礙的神經(jīng)保護作用及其機制研究[D]. 鄭為娜.河北醫(yī)科大學(xué) 2015
本文編號：2897694
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