發(fā)布時(shí)間：2018-12-30 10:41

【摘要】：目的:本研究擬探討引起急性膽系疾病患者肌鈣蛋白升高的臨床相關(guān)因素,進(jìn)一步提高對(duì)急性膽系疾病患者肌鈣蛋白升高的臨床認(rèn)識(shí)。方法:連續(xù)收集115例臨床上確診的急性膽系疾病患者,根據(jù)肌鈣蛋白檢測(cè)結(jié)果分為肌鈣蛋白升高組18例,肌鈣蛋白正常組97例,記錄納入樣本的臨床資料,包括性別、年齡、既往有無冠心病及其等危癥、急性膽系疾病病情嚴(yán)重程度、膽囊擴(kuò)張或膽管擴(kuò)張等,采用Logistic回歸分析急性膽系疾病患者合并肌鈣蛋白升高的相關(guān)危險(xiǎn)因素。結(jié)果:在115例確診急性膽系疾病的患者中,18例患者肌鈣蛋白升高,發(fā)生率為15.65%,通過單因素分析發(fā)現(xiàn)急性膽系疾病病情嚴(yán)重程度,C反應(yīng)蛋白(CRP)、谷丙轉(zhuǎn)氨酶(ALT)、谷草轉(zhuǎn)氨酶(AST)、總膽紅素(TBIL)、膽管擴(kuò)張與急性膽系疾病肌鈣蛋白升高差異有統(tǒng)計(jì)學(xué)意義(P0.05),通過多因素Logistic回歸分析顯示C反應(yīng)蛋白(OR=1.052;90%CI,1.024~1.082),ALT(OR=1.006;90%CI,1.002~1.011),疾病嚴(yán)重程度(OR=4.681;90%CI,1.132~19.361)是急性膽系疾病患者肌鈣蛋白升高的獨(dú)立危險(xiǎn)因素。α入=0.05,α出=0.10,P0.1有統(tǒng)計(jì)學(xué)意義。結(jié)論:C反應(yīng)蛋白(CRP)、谷丙轉(zhuǎn)氨酶(ALT)、疾病病情嚴(yán)重程度是急性膽系疾病患者肌鈣蛋白升高的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective: to investigate the clinical factors related to the elevation of cardiac troponin in patients with acute biliary diseases and to improve the clinical understanding of the elevation of troponin in patients with acute biliary diseases. Methods: 115 patients with acute biliary diseases were collected and divided into 18 patients with elevated troponin and 97 patients with normal cardiac troponin according to the results of cardiac troponin test. The clinical data including sex and age were recorded. Logistic regression analysis was used to analyze the risk factors associated with elevated cardiac troponin in patients with acute biliary diseases such as coronary heart disease (CHD) and its isotherapies, severity of acute biliary diseases, gallbladder dilatation or bile duct dilatation. Results: of the 115 patients with acute biliary diseases, 18 had elevated troponin (15.65%). The severity of acute biliary diseases and C-reactive protein (CRP),) were found by univariate analysis. Glutamic pyruvic transaminase (ALT),) and total bilirubin (TBIL), (AST),) were significantly higher than those in acute biliary diseases (P0.05). Identification of C-reactive protein (OR=1.052;) by multivariate Logistic regression analysis 90CIN 1.024 1.082), ALT (OR=1.006;90%CI,1.002~1.011), severity of disease (OR=4.681;) 90CII 1.132 ~ 19.361) is an independent risk factor for the elevation of cardiac troponin in patients with acute biliary diseases, 偽 -input = 0.05, 偽 -output = 0.10p _ (0.1). Conclusion: the severity of C-reactive protein (CRP), glutamate-alanine aminotransferase (ALT),) disease is an independent risk factor for the elevation of troponin in patients with acute biliary diseases.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R575.6

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