發(fā)布時(shí)間：2018-12-30 15:39

【摘要】：目的研究西蘭司瓊對(duì)腸易激綜合征(IBS)的臨床治療效果,探討西蘭司瓊治療IBS的機(jī)制。方法選取2014年7月-2015年10月在該院就診的IBS患者80例,隨機(jī)分為兩組:觀察組46例(口服西蘭司瓊8 mg,3次/d,連續(xù)服用6 d)、對(duì)照組34例(口服維生素C片50 mg,3次/d,連續(xù)服用6 d)。運(yùn)用羅馬Ⅲ標(biāo)準(zhǔn)對(duì)治療結(jié)果進(jìn)行評(píng)價(jià),并運(yùn)用免疫組織化學(xué)法分別測(cè)定回盲部黏膜肥大細(xì)胞(MC)數(shù)目、脫顆粒比率及高效液相電化學(xué)法測(cè)定5-HT濃度,記錄治療過(guò)程中的不良反應(yīng)及不良反應(yīng)率。結(jié)果治療后,觀察組顯效率和總有效率與對(duì)照組比較,差異均有統(tǒng)計(jì)學(xué)意義(P0.05),觀察組患者的MC數(shù)目和MC脫顆粒比率較對(duì)照組均減少,差異有統(tǒng)計(jì)學(xué)意義(P0.05),觀察組患者5-HT濃度恢復(fù)正常,且高于對(duì)照組(P0.05);治療前后治療組患者M(jìn)C數(shù)目,MC脫顆粒比率以及5-HT濃度下降值均高于對(duì)照組(P0.05)。結(jié)論西蘭司瓊對(duì)IBS癥狀具有治療作用,可降低回盲部黏膜MC數(shù)目及脫顆粒比例,并可能通過(guò)與調(diào)節(jié)5-HT信號(hào)通路,來(lái)調(diào)節(jié)腸道運(yùn)動(dòng)有關(guān)。
[Abstract]:Objective to study the clinical effect of cilansetron on irritable bowel syndrome (IBS) and to explore the mechanism of cilansetron in the treatment of IBS. Methods Eighty patients with IBS from July 2014 to October 2015 were randomly divided into two groups: the observation group (n = 46) (oral cilanisetron 8 mg,3 / d) and the control group (n = 34) who took 6 d), orally for 50 mg,. 3 times / d, 6 d). The results of treatment were evaluated by Rome 鈪，

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